國家衛生研究院 NHRI:Item 3990099045/16115
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16115


    Title: Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan
    Authors: Tao, MH;Chuang, SC;Wu, IC;Chan, HT;Cheng, CW;Chen, HL;Lee, MM;Chang, HY;Hsiung, CA;Hsu, CC
    Contributors: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    Abstract: Purpose Previous cross-sectional studies have shown that higher magnesium intake is associated with better cognitive function, particularly in individuals with sufficient vitamin D status. The aim of this study was to evaluate the longitudinal associations between magnesium intake and cognitive impairment in a community-based cohort study in Taiwan. Methods The study population included 5663 community-dwelling adults aged >= 55 years old recruited from 2009 to 2013 and followed up from 2013 to 2020. Magnesium intake was evaluated from a validated food frequency questionnaire at baseline. Cognitive performance was measured at baseline and follow-up for participants' Mini-Mental Status Examination (MMSE), Digit Symbol Substitution Test (DSST), and Clock-Drawing Test (CDT), and impairment was defined as MMSE < 24, DSST < 21, and CDT < 3, respectively. Multivariate logistic regression models were used to examine the associations and were stratified by sex and plasma vitamin D levels (>= 50 or < 50 nmol/L). Results Higher baseline magnesium intake was associated with lower odds of a poor performance on the MMSE in both men and women (4th vs. 1st. quartile: OR = 0.43, 95% CI = 0.23-0.82, ptrend < 0.01 in men and OR = 0.53, 95% CI = 0.29-0.97, ptrend = 0.12 in women) and on the DSST in men (OR = 0.23, 95% CI = 0.09-0.61, ptrend < 0.01) at follow-up. Inverse associations between baseline magnesium intake and a poor performance on the MMSE or DSST were observed in men regardless of vitamin D status. Conclusion Our study suggested that higher magnesium intake was associated with the development of cognitive impairment in men in a median follow-up period of 6 years.
    Date: 2024-09-06
    Relation: European Journal of Nutrition. 2024 Sep 06;Article in Press:13.
    Link to: http://dx.doi.org/10.1007/s00394-024-03490-z
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1436-6207&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001308078600002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85203261119
    Appears in Collections:[Shu-Chun Chuang] Periodical Articles
    [I-Chien Wu] Periodical Articles
    [Hsing-Yi Chang] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles

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