國家衛生研究院 NHRI:Item 3990099045/16134

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Title:	Carbon dots in photodynamic therapy: The role of dopant and solvent on optical and photo-responsive properties
Authors:	Wibowo, A;Jahir Khan, M;Sansanaphongpricha, K;Khemthong, P;Laosiripojana, N;Yu, YS;Wu, KC;Sakdaronnarong, C
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Carbon dots (CDs) are novel carbon-based luminescent materials with wide-ranging applications in biosensing, bioimaging, drug transportation, optical devices, and beyond. Their advantageous attributes, including biocompatibility, biodegradability, antioxidant activity, photostability, small particle size (<10 nm), and strong light absorption and excitation across a broad range of wavelengths, making them promising candidates in the field of photodynamic therapy (PDT) as photosensitizers (PSs). Further enhancements in functionality are imperative to enhance the effectiveness of CDs in PDT applications, notwithstanding their inherent benefits. Recently, doping agents and solvents have been demonstrated to improve CDs' optical properties, solubility, cytotoxicity, and organelle targeting efficiency. These improvements result from modifications to the CDs' carbon skeleton matrices, functional groups on the surface state, and chemical structures. This review discusses the modification of CDs with heteroatom dopants, dye dopants, and solvents to improve their physicochemical and optical properties for PDT applications. The correlations between the surface chemistry, functional groups, the structure of the CDs, and their optical characteristics toward quantum yield, redshift feature, and reactive oxygen species (ROS) generation, have also been discussed. Finally, the progressive trends for the use of CDs in PDT applications are also addressed in this review.
Date:	2024-09-25
Relation:	Chemistry-A European Journal. 2024 Sep 25;30(54):Article number e202400885.
Link to:	http://dx.doi.org/10.1002/chem.202400885
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0947-6539&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001322576800031
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85204927179
Appears in Collections:	[Chia-Wen Wu] Periodical Articles

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