國家衛生研究院 NHRI:Item 3990099045/16221
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    題名: Plasma leptin levels are lower in females, but not males, with ketamine use disorder
    作者: Huang, MC;Chiang, LJ;Chien, WH;Liu, TH;Chen, CH;Liu, YL
    貢獻者: Center for Neuropsychiatric Research
    摘要: Background: Ketamine has emerged as a prominent substance of misuse. Leptin, an adipocyte-derived polypeptide hormone, has been implicated in the development of addiction. Sex-specific changes in leptin levels have been demonstrated following acute ketamine administration; the persistence of long-term ketamine use on leptin levels is uncertain. Objectives: To assess the sex-difference of leptin levels, and their persistence, in individuals with ketamine use disorder (KUD) compared to healthy controls. Methods: Plasma leptin levels were measured in 62 healthy controls (37 males, 25 females) and 68 participants with KUD (50 males, 18 females) on the first day (baseline) and after 1 and 2 weeks of abstinence. As leptin levels are affected by body mass index (BMI), BMI-adjusted leptin (leptin/BMI ratio) was also examined. Mixed model for repeated measures was used to examine changes after ketamine abstinence. Results: Compared to same-sex controls, female, but not male, participants with KUD demonstrated lower leptin levels and leptin/BMI ratio at baseline, week 1, and week 2 (leptin levels: p = .001, 0.006 and 0.032, respectively; leptin/BMI ratio: p = .004, 0.022, and 0.09, respectively). Repeated measures showed that leptin levels and the leptin/BMI ratio increased after 2 weeks of abstinence in male participants with KUD (p = .002 and 0.011, respectively), but females did not show such an increase (p > .05). Conclusions: Sex-specific differences were observed in leptin levels and the leptin/BMI ratio in individuals with KUD compared to controls. Lower leptin levels in females with KUD persisted after 2 weeks of abstinence.
    日期: 2024-10-21
    關聯: American Journal of Drug and Alcohol Abuse. 2024 Oct 21;Article in Press.
    Link to: http://dx.doi.org/10.1080/00952990.2024.2394963
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001339832900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85207274788
    顯示於類別:[劉玉麗] 期刊論文

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