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http://ir.nhri.org.tw/handle/3990099045/16254
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| Title: | Detection in orchards of predominant azole-resistant Candida tropicalis genotype causing human candidemia, Taiwan |
| Authors: | Tseng, KY;Chen, YZ;Zhou, ZL;Tsai, JN;Tseng, MN;Liu, HL;Wu, CJ;Liao, YC;Lin, CC;Tsai, DJ;Chen, FJ;Hsieh, LY;Huang, KC;Huang, CH;Chen, KT;Chu, WL;Lin, CM;Shih, SM;Hsiung, CA;Chen, YC;Sytwu, HK;Yang, YL;Lo, HJ |
| Contributors: | National Institute of Infectious Diseases and Vaccinology;Institute of Population Health Sciences |
| Abstract: | Fluconazole-resistant clade 4 Candida tropicalis causing candidemia in humans has been detected in tropical/subtropical areas, including those in China, Singapore, and Australia. We analyzed 704 individual yeasts isolated from fruits, soil, water, and farmers at 80 orchards in Taiwan. The most common pathogenic yeast species among 251 isolates recovered from farmers were Candida albicans (14.7%) and C. parapsilosis (11.6%). In contrast, C. tropicalis (13.0%), C. palmioleophila (6.6%), and Pichia kudriavzevii (6.0%) were prevalent among 453 environmental isolates. Approximately 18.6% (11/59) of C. tropicalis from the environment were resistant to fluconazole, and 81.8% (9/11) of those belonged to the clade 4 genotype. C. tropicalis susceptibility to fluconazole correlated with susceptibilities to the agricultural azole fungicides, difenoconazole, tebuconazole, and triadimenol. Tandem gene duplications of mutated ERG11 contributed to azole resistance. Agriculture environments are a reservoir for azole-resistant C. tropicalis; discontinuing agricultural use of azoles might reduce emergence of azole-resistant Candida spp. strains in humans. |
| Date: | 2024-11 |
| Relation: | Emerging Infectious Diseases. 2024 Nov;30(11):2323-2332. |
| Link to: | http://dx.doi.org/10.3201/eid3011.240545 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1080-6059&DestApp=IC2JCR |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85207346954 |
| Appears in Collections: | [吳綺容] 期刊論文
[陳逢叡] 期刊論文
[陳宜君] 期刊論文
[司徒惠康] 期刊論文
[羅秀容] 期刊論文
[廖玉潔] 期刊論文
[熊昭] 期刊論文
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| SCP85207346954.pdf | | 1091Kb | Adobe PDF | 16 | View/Open |
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