國家衛生研究院 NHRI:Item 3990099045/16269

NHRI > National Center for Geriatrics and Welfare Research > Shi-Heng Wang > Periodical Articles > Item 3990099045/16269

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16269

Title:	Association of polygenic liabilities for schizophrenia and bipolar disorder with educational attainment and cognitive aging
Authors:	Wu, CS;Hsu, CL;Lin, MC;Su, MH;Lin, YF;Chen, CY;Hsiao, PC;Pan, YJ;Chen, PC;Huang, YT;Wang, SH
Contributors:	National Center for Geriatrics and Welfare Research;Center for Neuropsychiatric Research
Abstract:	To elucidate the specific and shared genetic background of schizophrenia (SCZ) and bipolar disorder (BPD), this study explored the association of polygenic liabilities for SCZ and BPD with educational attainment and cognitive aging. Among 106,806 unrelated community participants from the Taiwan Biobank, we calculated the polygenic risk score (PRS) for SCZ (PRSSCZ) and BPD (PRSBPD), shared PRS between SCZ and BPD (PRSSCZ+BPD), and SCZ-specific PRS (PRSSCZvsBPD). Based on the sign-concordance of the susceptibility variants with SCZ/BPD, PRSSCZ was split into PRSSCZ_concordant/PRSSCZ_discordant, and PRSBPD was split into PRSBPD_concordant/PRSBPD_discordant. Ordinal logistic regression models were used to estimate the association with educational attainment. Linear regression models were used to estimate the associations with cognitive aging (n = 27,005), measured by the Mini-Mental State Examination (MMSE), and with MMSE change (n = 6194 with mean follow-up duration of 3.9 y) in individuals aged >= 60 years. PRSSCZ, PRSBPD, and PRSSCZ+BPD were positively associated with educational attainment, whereas PRSSCZvsBPD was negatively associated with educational attainment. PRSSCZ was negatively associated with MMSE, while PRSBPD was positively associated with MMSE. The concordant and discordant parts of polygenic liabilities have contrasting association, PRSSCZ_concordant and PRSBPD_concordant mainly determined these effects mentioned above. PRSSCZvsBPD predicted decreases in the MMSE scores. Using a large collection of community samples, this study provided evidence for the contrasting effects of polygenic architecture in SCZ and BPD on educational attainment and cognitive aging and suggested that SCZ and BPD were not genetically homogeneous.
Date:	2024-11-16
Relation:	Transl Psychiatry. 2024 Nov 16;14:Article number 472.
Link to:	http://dx.doi.org/10.1038/s41398-024-03182-6
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2158-3188&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001355645800001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85209402535
Appears in Collections:	[Shi-Heng Wang] Periodical Articles [Pei-Chun Chen] Periodical Articles [Chi-Shin Wu] Periodical Articles [Yen-Feng Lin] Periodical Articles

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