國家衛生研究院 NHRI:Item 3990099045/16286
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    题名: The role of PM2.5 exposure in lung cancer: Mechanisms, genetic factors, and clinical implications
    作者: Chen, CY;Huang, KY;Chen, CC;Chang, YH;Li, HJ;Wang, TH;Yang, PC
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Lung cancer is one of the most critical global health threats, as the second most common cancer and leading cause of cancer deaths globally. While smoking is the primary risk factor, an increasing number of cases occur in nonsmokers, with lung cancer in nonsmokers (LCNS) now recognized as the fifth leading cause of cancer mortality worldwide. Recent evidence identifies air pollution, particularly fine particulate matter (PM2.5), as a significant risk factor in LCNS. PM2.5 can increase oxidative stress and inflammation, induce genetic alterations and activation of oncogenes (including the epidermal growth factor receptor, EGFR), and contribute to lung cancer progression. This review summarizes the current understanding of how exposure to PM2.5 induces lung carcinogenesis and accelerates lung cancer development. It underscores the importance of prevention and early detection while calling for targeted therapies to combat the detrimental effects of air pollution. An integrated approach that combines research, public health policy, and clinical practice is essential to reduce the lung cancer burden and improve outcomes for those affected by PM2.5 exposurrre.
    日期: 2024-11-22
    關聯: EMBO Molecular Medicine. 2024 Nov 22;Article in Press.
    Link to: http://dx.doi.org/10.1038/s44321-024-00175-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1757-4676&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001360934800001
    显示于类别:[張雅媗] 期刊論文

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