國家衛生研究院 NHRI:Item 3990099045/16287
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16287


    Title: Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report
    Authors: Blechter, B;Hsiung, CA;Wang, X;Zhang, H;Seow, WJ;Shi, J;Chatterjee, N;Kim, HN;Wong, MP;Hong, YC;Wong, JY;Dai, J;Hosgood, HD;Wang, Z;Chang, IS;Choi, J;Wang, J;Song, M;Hu, W;Zheng, W;Kim, JH;Zhou, B;Albanes, D;Shin, MH;Chung, LP;An, SJ;Zheng, H;Yatabe, Y;Zhang, XC;Kim, YT;Shu, XO;Kim, YC;Vermeulen, RCH;Bassig, BA;Chang, J;Man Ho, JC;Ji, BT;Kubo, M;Daigo, Y;Momozawa, Y;Kamatani, Y;Honda, T;Kunitoh, H;Watanabe, SI;Miyagi, Y;Nakayama, H;Matsumoto, S;Tsuboi, M;Goto, K;Yin, Z;Takahashi, A;Goto, A;Minamiya, Y;Shimizu, K;Tanaka, K;Wu, T;Wei, F;Su, J;Kim, YH;Oh, IJ;Fun Lee, VH;Su, WC;Chen, YM;Chang, GC;Chen, KY;Huang, MS;Lin, HC;Seow, A;Park, JY;Kweon, SS;Chen, CJ;Gao, YT;Wu, C;Qian, B;Lu, D;Liu, J;Jeon, HS;Hsiao, CF;Sung, JS;Tsai, YH;Jung, YJ;Guo, H;Hu, Z;Chen, TY;Burdett, L;Yeager, M;Hutchinson, A;Berndt, SI;Wu, W;Wang, J;Choi, JE;Park, KH;Sung, SW;Liu, L;Kang, CH;Chen, CH;Xu, J;Guan, P;Tan, W;Wang, CL, .;al, et
    Contributors: Institute of Population Health Sciences;National Institute of Cancer Research
    Abstract: We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the epidermal growth factor receptor (EGFR) gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4,544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared to EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (OR=8.63, 95% CI:5.67, 13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (OR=3.50, 95% CI: 2.44, 5.00) (p-heterogeneity=3.66x10(-3)). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.
    Date: 2024-11-22
    Relation: Journal of Thoracic Oncology. 2024 Nov 22;Article in Press.
    Link to: http://dx.doi.org/10.1016/j.jtho.2024.11.019
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1556-0864&DestApp=IC2JCR
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles
    [I-Shou Chang] Periodical Articles

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