本发明揭示一种在水包油包水（W/O/W）乳液中的组合物，其组成成分包括：（a）含H2 O的连续水相；（b）分散在连续水相间的油相或油壳；以及（c）用于稳定连续水相和油相(或油壳)界面的亲水性聚合物，使其形成水包油（O/W）乳液。油相或油壳包括：（i）油、（ⅱ）分散在油或油壳内的内部水相，以及（ⅲ）一亲脂性山梨醇酐‑聚酯复合体，可稳定油和内部水相之间的界面，以形成油包水（W/O）乳液。该亲脂性山梨醇酐‑聚酯复合体包含：（1）山梨醇酐，以及（2）接合到山梨醇酐上的丙交酯‑己内酯共聚物或聚乳酸。A composition in a water-in-oil-in-water (W/O/W) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising H2O; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (W/O/W) emulsion. The oil phase or the oil shell comprises: (i) oil; (ii) an internal aqueous phase, dispersed within the oil or the oil shell; and (iii) a lipophilic sorbitan-polyester conjugate, stabilizing an interface between the oil and the inner aqueous phase to form a water-in-oil (W/O) emulsion. The lipophilic sorbitan-polyester conjugate comprises: (1) sorbitan; and (2) poly(lactide-co-Epsilon-caprolactone) or polylactic acid (polylactide), conjugated to the sorbitan.
