Background :Growing evidence suggests that childhood maltreatment is an important risk factor for lifelong negative consequences of health outcomes; however, there has not been a systematic investigation of the impact of childhood maltreatment on health outcomes in adulthood. We aim to investigate the impact of childhood maltreatment on disease burden and health and socioeconomic outcomes in adulthood. Methods: We utilized self-reported data on five subtypes of childhood maltreatment in the UK Biobank = 129,017). We first performed sex-combined and sex-stratified genome-wide association analyses to identify genomic loci associated with specific subtypes of childhood maltreatment. We then performed Mendelian randomization (MR) analyses to identify causal effects of childhood maltreatment on health and socioeconomic outcomes. Results: We identified two novel loci for emotional abuse in sex-combined analysis, one locus for emotional neglect in males, one locus for physical abuse in females, and one locus for sexual abuse in females. MR analyses showed that childhood maltreatment may increase the risk of anxiety disorders, major depressive disorder, migraine, stroke, and type 2 diabetes mellitus in adulthood. MR analysis also suggested childhood maltreatment may increase the costs for healthcare in adulthood, decrease the lifespan, and lead to lower educational attainment. Discussion: Our study elucidates the influence of childhood maltreatment on health outcomes in adulthood, highlighting the enduring influence of childhood maltreatment on lifelong health consequences and their associated healthcare costs. It is important to develop prevention strategies to lower the incidence of childhood maltreatment and provide support and care for victims of childhood maltreatment for better long-term health outcomes in the population.
日期:
2024-10
關聯:
European Neuropsychopharmacology. 2024 Oct;87(Suppl. 1):207.
