國家衛生研究院 NHRI:Item 3990099045/16422
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16422


    Title: Role of pge2-regulated neuroinflammation in constructing neuron-nk-glioma circuit for glioblastoma
    Authors: Chen, HC;Chang, WC;Hsu, TY
    Contributors: NHRI Graduate Student Program
    Abstract: Glioblastoma (GBM), known for its aggressive nature and poor prognosis, frequently recurs and resists standard treatments such as temozolomide (TMZ). This resistance is partly due to complex interactions within the tumor microenvironment, particularly involving neuronal excitation. Recent insights suggest that neuronal activity, through mechanisms like neurogliomal synapses, not only promotes glioma cell proliferation but also contributes to the chemoresistance observed in recurrent tumors. Our focus is on Prostaglandin E2 (PGE2), a mediator that regulates neuronal excitation, and its role in the recurrence and resistance of GBM. We discovered that PGE2 upregulates synaptic proteins and alters neurotransmitter profiles, enhancing tumor cell survival and resistance to TMZ. Specifically, increased levels of neurotransmitters such as glutamine and asparagine were observed in PGE2-rich environments, correlating with heightened chemoresistance and tumor recurrence. Co-culture experiments further demonstrated that PGE2-treated neuronal cells could induce resistance in adjacent GBM cells. These findings highlight the potential of targeting PGE2 pathways as a therapeutic strategy. A significant advancement in our study was the development and application of compound #038, a novel celecoxib derivative designed to cross the blood-brain barrier (BBB). This compound demonstrated enhanced efficacy in inhibiting GBM growth and improving survival rates in mouse models, indicating its potential as an effective therapeutic agent against GBM.
    Date: 2024-11-11
    Relation: Neuro-Oncology. 2024 Nov 11;26(Suppl. 8):viii49.
    Link to: http://dx.doi.org/10.1093/neuonc/noae165.0193
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001362566100043
    Appears in Collections:[Others] Conference Papers/Meeting Abstract

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