國家衛生研究院 NHRI:Item 3990099045/16423
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16423


    Title: Gamma knife radiosurgery for orbital cavernous hemangioma: A systematic review and single-arm meta-analysis
    Authors: Chen, HC;Franklin, B;Punukollu, A;Pineda, F;Palavani, L
    Contributors: NHRI Graduate Student Program
    Abstract: Gamma knife radiosurgery (GKRS) for orbital cavernous hemangioma (OCH) has emerged as a promising method due to its significant clinical improvement and low incidence of complications. This study aimed to evaluate the safety and efficacy of GKRS for the treatment of OCH. Following the PRISMA framework, we searched PubMed, Cochrane Central, and Embase for studies reporting outcomes of GKRS for OCH, including complications, visual improvement, proptosis, tumor reduction rate, and tumor progression rate. From 1856 search results, six studies with 100 patients were included. Only five minor complications related to GKRS were reported, including three with orbital pain and two with periorbital chemosis, resulting in a complication rate of 13% (95% CI: 7% - 25%). Visual acuity and visual field improvement rates after GKRS were 80% (95% CI: 63% - 96%) and 71% (95% CI: 47% - 95%), respectively. Proptosis improved in 94% of cases (95% CI: 83% - 100%). The tumor reduction rate was 77% after GKRS (95% CI: 69% - 85%). In conclusion, GKRS for OCH appears to be a safe technique, as evidenced by the rate of clinical improvement and radiological improvement. However, studies are limited by the absence of a control group, and additional studies are needed to evaluate the relative efficacy of GKRS compared with alternative surgical modalities for OCH.
    Date: 2024-11-11
    Relation: Neuro-Oncology. 2024 Nov 11;26(Suppl. 8):viii79-viii80.
    Link to: http://dx.doi.org/10.1093/neuonc/noae165.0317
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001362575500044
    Appears in Collections:[Others] Conference Papers/Meeting Abstract

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