國家衛生研究院 NHRI:Item 3990099045/16426
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12500/13673 (91%)
造访人次 : 2842716      在线人数 : 389
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16426


    题名: Prognosis of periprosthetic fractures post hip fracture: Unveiling protective role of anti-osteoporotic medication
    作者: F, SH;Kuan, YH;H, CC;Y, RS;L, CY;W, CY
    贡献者: National Center for Geriatrics and Welfare Research
    摘要: Objective: Periprosthetic fractures (PPF) near prior hip fracture fixation implants present formidable challenges due to intricate fracture patterns, implant presence, and compromised patient bone quality. Limited research exists on PPF prognosis in osteoporotic hip fracture patients. While anti-osteoporotic medication (AOM) effectively reduces secondary hip fracture risks, its impact on PPFs remains unexplored. Our study aims to address these gaps by assessing the influence of initiating AOM post-hip fracture on PPF occurrence and investigating PPF prognosis in a nationwide cohort of hip fracture patients. Methods: This nationwide cohort study employs Taiwan’s National Health Insurance Research Database (NHIRD) from January 1, 2016, to December 31, 2018, identifying 48,082 hospitalized hip fracture patients with concomitant procedures. Collected demographics include age, gender, comorbidities, and comedications. AOM use within one year post-hip fracture was examined. Primary outcome: periprosthetic fracture risk post-incident hip fracture. Secondary outcomes: subsequent osteoporotic fractures and PPF patient mortality. Fine and Gray’s subdistribution hazard function explored risk factors and AOM effects on PPF. Results: Among 48,082 patients with incident hip fractures, 30,182 (62.7%) were female, mean age 77.9 ± 10.7 y. Over 5 y, 443 (0.92%) developed PPF, with failure probability ranging from 0.58% (first year) to 1.25% (5-y follow-up). AOM users had lower cumulative PPF incidence at 5 y (0.53 vs. 1.08%). AOM post-hip fracture reduced PPF risk by 50% (HR = 0.5, p < 0.0001). Among 443 PPF patients, 22 (4.97%) had subsequent osteoporotic fractures, and 72 (16.25%) died within one year. Conclusion: PPF following an incident hip fracture escalates the risk of imminent fractures and mortality within a year. Employing AOM post-hip fracture may effectively mitigate the risk of PPF.
    日期: 2024-08-20
    關聯: Aging Clinical and Experimental Research. 2024 Aug 20;36:S266.
    Link to: http://dx.doi.org/10.1007/s40520-024-02766-y
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001363175502221
    显示于类别:[王貞予] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI001363175502221.pdf448KbAdobe PDF32检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈