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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/16429
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| Title: | Trends of vertebral height loss in normal older population |
| Authors: | Chan, CH;Lu, YC;Wu, HY;Chan, WP |
| Contributors: | National Center for Geriatrics and Welfare Research |
| Abstract: | Objective: To use an automatic vertebral compression fracture (VCF) detection method to investigate the percentage of vertebral height loss of normal aging population and to determine the differences in sex, age, and vertebrate level. Specific objectives included (1) the occurrence of the most severe VCFs in each sex, vertebral level and age group; (2) the distribution of the percentage of vertebral height loss by vertebral level, age, sex; and (3) the range of percentage of vertebral height loss by normal aging population. Methods: All non-contrast MDCT images of 856 participants (300 women) with an average age of 59.6 y (aged 50–95) were collected between 4 January 2021 and 31 March 2022. The MDCT images were reconstructed into 2.5 mm thick slices for automatic VCF analysis by SmartBone software. The subjects were divided into seven age groups, each of 5 y. We assessed differences in VCF between seven groups and two sexes using ANOVA and independent T tests. The normal range of the percentage of vertebral height loss with a combination of all vertebral levels during normal aging using the normal distribution estimation method (95%CI) and the interquartile range method (1.5 interquartile range). Results: The results showed that the most severe VCF usually occurred at T7, T11, and T12 in men. However, women generally had the most severe VCF from T5 to T8 between the ages of 50–60, and in the latter, the most severe VCF concentrated in T8. In addition, the increasing trends in vertebral height loss percentages by vertebral level and age group in men and women, and the progress in vertebral height loss in women, was similar to those in men. The percentage of vertebral height loss in the normal range of all age groups of both sexes exceeded 25%, where men and women losing 33% of vertebral height between 70–80 y of age. Conclusion: For the first time, our results show trends in reduction in vertebral height during normal aging in older Asians, thereby providing a reference database for clinical practice in the diagnosis and treatment of osteoporotic compression fractures. |
| Date: | 2024-08-20 |
| Relation: | Aging Clinical and Experimental Research. 2024 Aug 20;36:S600. |
| Link to: | http://dx.doi.org/10.1007/s40520-024-02766-y |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001363175504211 |
| Appears in Collections: | [其他] 會議論文/會議摘要
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| ISI001363175504211.pdf | | 87Kb | Adobe PDF | 3 | View/Open |
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