 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12340/13424 (92%)
Visitors : 1999822
Online Users : 192
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/16465
|
| Title: | Long-term exposure to multiple air pollutants and risk of Parkinson's disease: A population-based multipollutant model study |
| Authors: | Chen, SJ;Pan, SC;Wu, CD;Li, H;Guo, YL;Lin, CH |
| Contributors: | National Institute of Environmental Health Sciences |
| Abstract: | BACKGROUND: Recent evidence suggests brain-first Parkinson's disease (PD) may start from the olfactory system, indicating potential inhalational exposure to causal agents. We investigated the impact of long-term exposure to various air pollutants on PD incidence using both single- and multi-pollutant models to account for interactions between pollutants. METHODS: This retrospective population study used data from Taiwan's National Health Insurance Research Database (2006 and 2018) and included individuals aged 40-65 without PD. Personal exposure levels to various air pollutants, including PM(2.5), PM(10), NO(2), O(3), SO(2) and CO, were calculated using the hybrid Kriging/land-use regression method. Cox regression models were used to analyse the association between pollutants and PD incidence, adjusting for covariates. RESULTS: A total of 5 113 322 individuals without PD (mean age 50.1±6.9 years, 47.3% men) were followed for an average of 11.2±2.4 years, during which 20 694 incident cases of PD were identified. In the single-pollutant model, exposure to PM(2.5) (HR 2.65 (95% CI 2.59 to 2.72)), PM(10) (HR 3.13 (3.04 to 3.22)), NO(2) (HR 1.74 (1.68 to 1.80)) and SO(2) (HR 1.68 (1.65 to 1.71)) was associated with an increased risk of PD. These associations remained robust in the multipollutant model. A positive association between exposure to O(3) and an increased risk of PD (HR 1.29 (1.25-1.33)) was observed after adjusting for co-pollutants. CONCLUSIONS: This nationwide cohort study employing multiple-pollutant models for considering the interaction effects revealed an association between exposure to multiple air pollutants and the risk of PD, emphasising the need for early prevention strategies. |
| Date: | 2024-12-27 |
| Relation: | Journal of Neurology, Neurosurgery, and Psychiatry. 2024 Dec 27;Article in Press. |
| Link to: | http://dx.doi.org/10.1136/jnnp-2024-334825 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001386103300001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85214459660 |
| Appears in Collections: | [郭育良] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| PUB39730198.pdf | | 1717Kb | Adobe PDF | 15 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
