國家衛生研究院 NHRI:Item 3990099045/16691
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    題名: Heterocyclic compounds and use thereof
    作者: Shia, KS;Jan, JJ;Tsou, LK;Chen, CT;Chao, YS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: FIELD: chemistry.SUBSTANCE: invention relates to a novel heterocyclic compound of formula (I). In formula (I), each of Rand Rindependently represents H, a halogen atom, an amino, Calkyl, Cheterocycloalkyl containing in ring 1–2 nitrogen atoms or nitrogen atom and oxygen atom; or Rand Rtogether with two carbon atoms to which they are bonded, are Cheterocycloalkyl containing a nitrogen atom as a heteroatom, phenyl or 5-member heteroaryl containing a nitrogen atom in the cycle, a sulphur atom or two nitrogen atoms, where each of the Cheterocycloalkyl, phenyl and heteroaryl is optionally substituted with a halogen atom, Calkyl, Calkoxy or C(O)OR, in which Ris H or Calkyl; and each of Rand Rindependently represents NRR,or, wherein at least one of Rand Ris, in which each of Rand Rindependently represents H or Calkyl; Ris H, Calkyl, benzyl, optionally substituted cyano, or 5-member heteroaryl Calkyl containing 2 nitrogen atoms as heteroatoms; Ris H; Lis 5-member heteroaryl containing 3 nitrogen atoms as heteroatoms, Cheterocycloalkyl containing 1–2 nitrogen atoms in a cycle, NH or NR, in which Ris C(O)(CH)CHNHCOR, where Ris H or Calkyl; Ris H, Calkyl, Calkoxy, Ccycloalkyl, Cheterocycloalkyl containing in the cycle a nitrogen atom or a nitrogen atom and an oxygen atom, phenyl or 5- or 6-member heteroaryl containing 1–3 nitrogen atoms as heteroatoms, wherein each of said Calkyl, Calkoxy, Ccycloalkyl, Cheterocycloalkyl, phenyl and heteroaryl is optionally substituted with hydroxy, hydroxy Calkyl, halogen atom, amino Calkyl, amino Ccycloalkyl, amino Cheterocycloalkyl, Ccycloalkyl, Cheterocycloalkyl containing a nitrogen atom and an oxygen atom in the cycle, phenyl, optionally substituted with halogen, or 5-member heteroaryl containing 2 nitrogen atoms as heteroatoms; m is 1–6; n is equal to 2–3; each of Rand Rindependently represents H or Calkyl; or Rand Rtogether with nitrogen atoms with which they are bonded, are Cheterocycloalkyl; Lis Calkyl; or Ltogether with Ror Rand nitrogen atom, with which they are bonded, is Cheterocycloalkyl. Other radical values are specified in the patent claim.EFFECT: compound has activity on CXCR4 type 4 chemokine receptor (CXCR4) and can be used for treating a disease selected from renal damage, ischemic disease, cancer and myocardial infarction; and the compound can also be used to mobilize haemopoetic stem cells (HSC) and endothelial progenitor cells (EEC) in peripheral circulation.29 cl, 4 ex
    日期: 2019-10-23
    關聯: RU2704008/2019-10-23
    Link to: https://tiponet.tipo.gov.tw/gpss2/gpsskmc/gpssbkm?!!FRURLRU2704008C2
    顯示於類別:[夏克山] 專利
    [鄒倫] 專利
    [陳炯東] 專利
    [趙宇生(2002-2013)] 專利

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