國家衛生研究院 NHRI:Item 3990099045/1671
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856560      線上人數 : 706
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1671


    題名: Adiponectin levels among patients with chronic hepatitis B and C infections and in response to IFN-alpha therapy
    作者: Lu, JY;Chuang, LM;Yang, WS;Tai, TY;Lai, MY;Chen, PJ;Kao, JH;Lee, CZ;Lee, HS
    貢獻者: Division of Gerontology Research
    摘要: Aims: The study was designed to survey the change of adiponectin levels before and after interferon-alpha (IFN-alpha) therapy in patients with chronic hepatitis B and C infections. Methods: Twenty-one biopsy-proved patients with chronic hepatitis B (10 cases) and hepatitis C (11 cases) were given IFN-alpha for a total of 24 weeks. Fasting plasma glucose, insulin and adiponectin levels were obtained before and 12 weeks after completion of IFN-alpha therapy. Insulin suppression test was conducted before and within 1 week after IFN-alpha therapy. Results: The change of adiponectin levels differed significantly between responders (eight cases) and non-responders (13 cases) to IFN-alpha treatment (-4.8 +/- 2.2 vs. 0.5 +/- 1.0 mu g/ml, P=0.03). After adjusting for age, gender and change in body mass index, the study found the change of adiponectin levels still significantly related to the response to IFN-alpha (P=0.04). When hepatitis B virus (HBV) and hepatitis C virus (HCV)-infected patients were separately analyzed, the adiponectin levels reported a trend to decrease in HCV responders (11.9 +/- 3.2 vs. 10.8 +/- 3.0 mu g/ml, P=0.02, n=4) and HBV responders (17.7 +/- 4.1 vs. 9.2 +/- 1.0 mu g/ml, P=0.10, n=4). In addition, a significant decrease of steady-state plasma glucose in insulin suppression test was noted in responders (13.6 +/- 1.8-11.7 +/- 1.2 mmol/l, P=0.03), but not in non-responders (12.3 +/- 1.1-11.0 +/- 1.0 mmol/l, P=0.20), after IFN-alpha therapy. Conclusions: IFN-alpha resulted in a decrease of serum adiponectin levels but an improvement of insulin resistance in responders to the treatment. The result contradicts previous concept of the relationship between insulin resistance and adiponectin levels. Whether and how the augmented immune response, which was supposed to result from the disappearance or the profound down-regulation of the virus or viral antigens in responders to IFN-alpha treatment, contributes to the lowering of adiponectin levels needs to be further investigated.
    關鍵詞: Gastroenterology & Hepatology
    日期: 2005-08
    關聯: Liver International. 2005 Aug;25(4):752-759.
    Link to: http://dx.doi.org/10.1111/j.1478-3231.2005.1007.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1478-3223&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000230302900011
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84984558810
    顯示於類別:[戴東原(2003-2005)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    000230302900011.pdf144KbAdobe PDF965檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋