國家衛生研究院 NHRI:Item 3990099045/1679
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    題名: Independent association between triglycerides and coronary artery disease in Taiwanese type 2 diabetic patients
    作者: Tseng, CH;Tseng, CP;Chong, CK;Cheng, JC;Tai, TY
    貢獻者: Division of Gerontology Research;Division of Environmental Health and Occupational Medicine
    摘要: Background: This study evaluated the association between triglycerides (TG) and coronary artery disease (CAD) in Taiwanese adults with type 2 diabetes mellitus (T2DM). Methods: A total of 1150 patients (542 men and 608 women) aged 62.5 +/- 11.6 years were studied. CAD was diagnosed by history or an abnormal electrocardiogram (coronary probable or possible by Minnesota codes). Age, body mass index (BMI), smoking, use of insulin, antihypertensive kagents and lipid-lowering agents, fasting plasma glucose (FPG), hemoglobin A(1c) (HbA(1c)), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were considered as potential confounders. Results: Patients with CAD were older, had higher prevalences of use of anti-hypertensive and lipid-lowering agents, and had higher BMI, SBP, DBP and TG. CAD increased significantly with increasing quartiles of TG (P-trend < 0.001). Ln(TG) was significantly correlated with BMI, FPG, HbA(1c), DBP, TC, HDL-c (inversely) and LDL-c. Ln(TG) was associated with CAD with an unadjusted odds ratio of 1.411 (1.145-1.740). The odds ratio after adjustment for all confounders was slightly attenuated but still statistically significant: 1.380 (1.0431.826). None of the other lipid parameters of TC, HDL-c and LDL-c were significantly associated with CAD in logistic models when they were entered for adjustment either separately or simultaneously. Sensitivity analyses by using history alone or history and coronary probable as diagnostic criteria for CAD did not change the association between TG and CAD. Conclusions: TG is an independent risk factor for CAD in Taiwanese T2DM, independent of TC, HDL-c, LDL-c or other confounders.
    關鍵詞: Cardiac & Cardiovascular Systems
    日期: 2006-07-28
    關聯: International Journal of Cardiology. 2006 Jul;111(1):80-85.
    Link to: http://dx.doi.org/10.1016/j.ijcard.2005.07.021
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0167-5273&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000240044400013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746281189
    顯示於類別:[戴東原(2003-2005)] 期刊論文
    [其他] 期刊論文

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