一种分离的抗体，包含：重链可变区序列的重链互补决定区CDR1、CDR2和CDR3，该重链可变区序列系选自SEQ ID NOs：2、6、10和14；以及轻链可变区序列的轻链互补决定区CDR1、CDR2和CDR3，该轻链可变区序列系选自SEQ ID NOs：4、8、12和16；其中，该抗体与RSPO3蛋白特异性地结合。An isolated antibody comprises: heavy chain complementary determining regions CDR1, CDR2, and CDR3 of a heavy chain variable region sequence selected from SEQ ID NOs: 2, 6, 10, and 14; and light chaincomplementary determining regions CDR1, CDR2, and CDR3 of a light chain variable region sequence selected from SEQ ID NOs: 4, 8, 12, and 16, wherein the antibody binds specifically to a RSPO3 protein.
