國家衛生研究院 NHRI:Item 3990099045/16862
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12500/13673 (91%)
Visitors : 2635835      Online Users : 579
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16862


    Title: Oral squamous cell carcinoma-derived ISG15 enforces fibroblast recruitment via CD11a-dependent glycolysis reprogramming
    Authors: Chen, YW;Wang, S;Chen, YL;Huang, SH;Jiang, SS;Liu, SC;Hsiao, J;Chang, JY
    Contributors: National Institute of Cancer Research
    Abstract: The mechanisms underlying the crosstalk of oral squamous cell carcinoma (OSCC) cells and fibroblasts remain poorly investigated. We identified that ectopic expression of interferon stimulated gene 15 (ISG15) enhanced expression of collagen and alpha-smooth muscle actin (alpha-SMA) in ISG15-expressing tumors. The in vivo experiments confirmed fibroblast recruitment in ISG15-expressing OSCC tissues. And, exogenous ISG15 induced fibroblast migration, morphological changes and vimentin expression. Using geneset enrichment analysis (GSEA), the glycolysis pathway was enriched in ISG15-treated fibroblasts. The glucose consumption and lactate production were amplified in ISG15-treated fibroblast. Also, lactate release and fibroblast migration were blocked by 2-deoxy-d-glucose (2-DG), a competitive inhibitor of glucose metabolism. Furthermore, CD11a, a subunit of ISG15 receptor, lymphocyte function-associated antigen-1 (LFA-1), was involved in ISG15-meidated glycolysis and fibroblast migration. Our findings uncovered that OSCC-derived ISG15 bond to its receptors, LFA-1 on fibroblasts to activate glycolysis reprogramming and finally promote fibroblast movement.
    Date: 2024-03
    Relation: Cancer Science. 2024 Mar;115(Suppl. 1):781.
    Link to: https://onlinelibrary.wiley.com/toc/13497006/2024/115/S1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001390207201379
    Appears in Collections:[Ya-Wen Chen] Conference Papers/Meeting Abstract
    [Shih-Sheng Jiang] Conference Papers/Meeting Abstract

    Files in This Item:

    File Description SizeFormat
    ISI001390207201379.pdf505KbAdobe PDF20View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback