國家衛生研究院 NHRI:Item 3990099045/16867
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2644149      線上人數 : 302
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16867


    題名: Neuromedin U signaling promote pro-tumor microenvironment in lung cancer
    作者: Li, SM;Fan, CS;Fang, WS;Tsai, FY;Jao, HY;Chen, YW;Liu, K;Hsiung, CA;Jiang, SS
    貢獻者: National Institute of Infectious Diseases and Vaccinology;National Institute of Cancer Research;Institute of Population Health Sciences
    摘要: By using the GWAS approach, we have previously identified several genetic variants located on 4q12 that were significantly associated with PFS of patients with lung adenocarcinoma (ADC) receiving first-line EGFR-TKI therapy. Intriguingly, we found those genetic variants were significantly associated with expression level of NMU , which is known to be upregulated in lung ADC and significantly associated with patients' worse poor survival. Here we found that knockdown of NMU expression remarkedly suppressed lung ADC cell proliferation in vitro and xenograft tumor growth in mice model, while forced expression of NMU had exactly the opposite effects. Also, based on xenograft model of lung ADC in mice, we further found that NMU not only can promote cancer cell growth via autocrine effect, but also can affect other cell types, e.g., fibroblast cells via paracrine effect, to foster a pro-tumor milieu by providing survival advantages to cancer cells. Our findings may lead to innovation of novel biomarkers for stratification of patients for precision medicine of lung cancer (LC) and invention of new therapeutic agents that may benefit LC patients by improving their survival and prognosis.
    日期: 2024-03
    關聯: Cancer Science. 2024 Mar;115(Suppl. 1):1350.
    Link to: https://onlinelibrary.wiley.com/toc/13497006/2024/115/S1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001390207203077
    顯示於類別:[陳雅雯] 會議論文/會議摘要
    [劉柯俊] 會議論文/會議摘要
    [江士昇] 會議論文/會議摘要
    [熊昭] 會議論文/會議摘要
    [其他] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI001390207203077.pdf515KbAdobe PDF18檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋