國家衛生研究院 NHRI:Item 3990099045/16868
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    題名: High expression of CD80 promotes cell growth and stemness of oral squamous cell carcinoma cells
    作者: Huang, SH;Chen, YL;Cheng, JY;Chen, PY;Huang, HT;Wang, SH;Liu, KJ;Chuang, TH;Su, YW;Chen, YW
    貢獻者: National Institute of Cancer Research;Immunology Research Center
    摘要: Oral squamous cell carcinoma (OSCC) is a leading cause of morbidity and mortality in head and neck cancer patients. To evaluate the immunotherapy of OSCC in East Asian, we established a novel cell line, named NHRI-HN1, from a mouse tongue tumor induced by 4-NQO/arecoline. M1-2sph-T (sphT)and M1-2sph-N (sphN) cells were derived from orthotopic tumors and cervical lymph nodes of mice injected with NHRI-HN1 cells, respectively. Compared to NHRI-HN1 cells, sphT and sphN cells displayed faster tumor growth in mice, along with increased cell growth, migration, and sphere formation. These cells also showed enhanced activation of ERK and markers of EMT. Based on the gene expression array analysis, we found that both sphT and sphN cells showed higher expression levels of CD80 as compared with NHRI-HN1 cells. Knockdown of CD80 inhibited sphere formation and tumor growth of mouse OSCC cells. Also, the sphere formation and tumor growth were enhanced in mouse OSCC cells with high expression of CD80. We found CD80 expression was correlated with the expression of Sox2 and CD274 in mouse OSCC cells. The relationship among CD80, Sox2 and CD274 in OSCC cells was under investigation.
    日期: 2024-03
    關聯: Cancer Science. 2024 Mar;115(Suppl. 1):1425.
    Link to: https://onlinelibrary.wiley.com/toc/13497006/2024/115/S1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001390207203150
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