國家衛生研究院 NHRI:Item 3990099045/16870
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    題名: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) promotes progression of triple negative breast cancer
    作者: Tsai, HJ;Chang, TM;Hsu, HP;Chu, PY;Huang, KW;Jiang, SS;Lin, HY
    貢獻者: National Institute of Cancer Research
    摘要: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), which is encoded by PCK2, is up-regulated in various tumors, including breast cancer (BC). The role of PEPCK-M in the pathogenesis and progression of BC is largely unknown. Recently, we found that PEPCK-M is differentially expressed in BCs. High expression of PEPCK-M was noted in around half of triple negative BC (TNBC). We evaluated the function of PEPCK-M in TNBC. Knockdown of PCK2 reduced the proliferative rate of TNBC cells and delayed the cell cycle progression to S phase. In addition, knockdown of PCK2 attenuated invasion and migration of TNBC cells with reduced expression of smad3, snail-1 and slug. PCK2 positively regulated smad3 at transcriptional level. Knockdown of smad3 reduced expression of snail-1 and slug. In addition, knockdown of PCK2 attenuated the stimulatory effect of TGF-beta to smad3 phosphorylation in TNBC cells. Taken together, PCK2 not only promotes cell proliferation and cell cycle progression of TNBC but also promotes tumor invasion/migration via regulation of smad3. The result suggests that PEPCK-M may be a potential therapeutic target for the treatment of TNBC.
    日期: 2024-03
    關聯: Cancer Science. 2024 Mar;115(Suppl. 1):1536.
    Link to: https://onlinelibrary.wiley.com/toc/13497006/2024/115/S1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001390207203242
    顯示於類別:[蔡慧珍] 會議論文/會議摘要
    [江士昇] 會議論文/會議摘要

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