國家衛生研究院 NHRI:Item 3990099045/16888
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12500/13673 (91%)
造访人次 : 2597757      在线人数 : 398
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16888


    题名: More pronounced neuroaxonal integrity disturbances in methamphetamine-associated persistent psychosis compared to schizophrenia
    作者: Huang, MC;Liu, TH;Liu, YL
    贡献者: Center for Neuropsychiatric Research
    摘要: Background: Methamphetamine (METH) can cause multiple physical and psychological harms. Psychosis is one of the most serious health consequences from using METH, with this requiring aggressive treatment and being associated neurocognitive impairment and structural brain abnormalities. While the majority of METH-associated psychosis are brief (METH-associated brief psychosis, MBP); the psychosis can become persistent for >1 month in a subset of people (METH-associated persistent psychosis, MPP), with a symptom profile substantially similar to schizophrenia. Blood levels of neurofilament light chain (NFL) have been proposed as a measure of neuroaxonal integrity in several neuropsychiatric disorders. Aims & Objectives: We aimed to delineate the neuroaxonal damage linked to METH-associated psychosis, especially its persistent form, and compare it to schizophrenia. Methods: We enrolled 135 individuals with METH use disorder (55 with no psychosis [MNP group], 54 with MBP, and 24 with MPP), 78 with schizophrenia, and 85 healthy controls. Blood NFL levels measured by single molecule array (SiMoA) immunoassay. We compared NFL levels between different groups and used regression analyses to identify clinical variables related to NFL levels. Results: Individuals with MUD had significantly higher NFL levels compared to controls but comparable to patients with schizophrenia. We found age (p<.01) and duration of METH use (p = 0.01) were positively correlated with NFL levels whereas BMI is negatively correlated with NFL levels. Subsequent group comparisons showed that the NFL levels in MPP group were higher than MBP and MNP group while the levels were comparable between the latter two groups. Interestingly, MPP group had increased NFL levels compared to schizophrenia group. Furthermore, those with a prolonged psychosis associated with METH, i.e. schizophrenia-like, had a even higher NFL levels than all the resting groups. Discussion & Conclusions: These results suggest substantial neuroaxonal alterations following METH use, with a longer duration associated with higher injury. In particular, persistent psychosis The pronounced increase of NFL levels in the people with MPP and suffering from persistent psychosis might indicate that dual disruptive effect (from METH use and psychosis) on the neuroaxonal integrity and the pathology could differentiate MPP and schizophrenia.
    日期: 2025-02-12
    關聯: International Journal of Neuropsychopharmacology. 2025 Feb 12;28(Suppl. 1):i96-i97.
    Link to: http://dx.doi.org/10.1093/ijnp/pyae059.166
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001419872300001
    显示于类别:[劉玉麗] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI001419872300001.pdf1464KbAdobe PDF25检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈