國家衛生研究院 NHRI:Item 3990099045/16889
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2472788      線上人數 : 315
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16889


    題名: Explore the role of inflammatory pathway of Tnfr1 in alcohol dependence and the potential to differentiate delirium tremens
    作者: Liu, YL;Huang, MC;Liu, TH;Kuo, HW
    貢獻者: Center for Neuropsychiatric Research
    摘要: Background: Inflammatory factor TNF-alpha has been implicated in the pathophysiology of alcohol withdrawal syndrome (AWS) and craving phenomenon in relation to alcohol dependence (AD) [1]. Its binding to TNF receptor 1 (TNFR1) has also been reported to be involved in the apoptosis pathway [2] and to lead to neuronal cell death. Delirium tremens (DT) is a serious subtype of AWS and associated with high mortality if inadequately treated. Little is known about the role of the soluble form TNFR1 (sTNFR1) in patients with AD and its relationship with DT. Aims & Objectives: This study aimed to compare sTNFR1 levels in patients with AD who experience DT during withdrawal to those without DT, in comparison to healthy controls. Method: A total of 224 patients with AD who were admitted for alcohol detoxification treatment and 117 non- AD controls were recruited. Blood levels of sTNFR1, and the inflammatory C-C motif chemokine ligand 11 (CCL11) were evaluated using enzyme-linked immunosorbent assay (ELISA). In patients with AD, we assessed various alcohol-related variables, including, Obsessive Compulsive Drinking Scale (OCDS) scores, Penn Alcohol Craving Score (PACS), Clinical Institute Withdrawal Assessment for Alcohol Scale, revised (CIWA-Ar) scores, and Alcohol Craving Questionnaire-Short Form-Revised total score (ACQ-SF-R). Results: The AD group exhibited lower body mass index (BMI) and fewer years of education, but had higher rates of cigarette smoking, as well as elevated plasma CCL11 [3] and sTNFR1 levels compared to age and sex- matched controls (Mann-Whitney U test, P<0.0001). Within the AD group, 11.2% (n = 25) experienced DT during their admission, referred to as the DT group. The DT group exhibited significantly higher levels of sTNFR1 (P<0.0001) compared to the non-DT group. In addition, the DT group was characterized by older age (P≦0.023), elevated plasma CCL11 levels (P=0.049), and more severe withdrawal symptoms, as indicated by CIWA-Ar scores (P≦0.0002). They also displayed greater craving, as reflected in OCDS total scores (P≦0.009), as well as PACS (P≦0.01) and ACQ-SF-R (P≦0.011) scores. Multiple linear regression analysis showed that sTNFR1 was significantly correlated with the occurrence of DT (partial r2=0.039, P=0.003), as well as OCDS total (partial r2=0.091, P≦0.0003) and plasma CCL11 levels (partial r2 =0.028, P≦0.008). Furthermore, the receiver operating characteristic (ROC) curve demonstrated that an sTNFR1 level of 1,050 pg/mL could effectively differentiate the DT group from the non-DT group (area under the ROC curve: 0.79; sensitivity: 96.0%, specificity: 56.3%, p <0.001). Discussion & Conclusion: These results indicate that AD patients with DT exhibited higher levels of inflammation, as evidenced by increased plasma levels of sTNFR1 and CCL-11. Furthermore, sTNFR1 may have the potential to discriminate those with development of DT. In conclusion, these findings suggest that sTNFR1 plays a role in the neurobiological mechanisms underlying AD and modifying the phenotype of DT.
    日期: 2025-02-12
    關聯: International Journal of Neuropsychopharmacology. 2025 Feb 12;28(Suppl. 1):i297-i298.
    Link to: http://dx.doi.org/10.1093/ijnp/pyae059.528
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001419884300001
    顯示於類別:[劉玉麗] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI001419884300001.pdf1510KbAdobe PDF21檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋