國家衛生研究院 NHRI:Item 3990099045/16894
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2592633      線上人數 : 347
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16894


    題名: Effects of sodium benzoate on behavioral and synaptic deficits induced by subchronic ketamine exposure in mice
    作者: Chan, MH;Liu, YH;Chen, HH
    貢獻者: Center for Neuropsychiatric Research
    摘要: Background: Ketamine, an N-methyl-D-aspartate receptor (NMDAR) blocker, has been used as a dissociative anesthetic and currently become a popular recreational abused substance. Repeated and chronic use of ketamine leads to behavioral disturbances, including social deficits and cognitive impairments in memory. Previous studies indicate that enhancement of NMDAR function reveals the beneficial effects on ketamine-induced abnormal behavioral and neurochemical responses. Sodium benzoate (SB), a D-amino acid oxidase inhibitor, has been reported to improve several neurological disorders, such as depression and schizophrenia, which may be associated with increasing NMDAR function. Aims & Objectives: This study aimed to investigate the therapeutic effects of SB on ketamine- induced psychotomimetic behaviors and neuronal activity. Method: The male ICR mice received intraperitoneal injection (i.p.) of either ketamine (20 mg/kg) or vehicle twice per day successively during postnatal days (PN) 32-46. Subsequently, SB (30 &100 mg/kg, i.p.) was given during PN55-69. The novel location/object recognition task, reciprocal social interaction, three-chamber social test, tail suspension test and forced swimming test were monitored. Moreover, a serotonergic hallucinogen was administered to induce head-twitch responses. After animal behavioral tests, the hippocampal synaptic function was determined. Results: The data showed that the enduring behavioral abnormalities after repeated ketamine exposure, including social deficits, recognition memory impairments, and increased depression- like and hallucinogen-induced head-twitch responses, were ameliorated by SB post-treatment. In addition, SB reversed the reduced hippocampal synaptic activity after repeated ketamine treatment. Discussion & Conclusion: These results demonstrated that post-treatment with SB could effectively reverse the adverse behavioral manifestations and hippocampal synaptic plasticity after repeated ketamine use, suggesting that SB can be used as a novel adjunct therapy with ketamine for treatment- resistant depression and provide benefits for ketamine use disorders.
    日期: 2025-02-12
    關聯: International Journal of Neuropsychopharmacology. 2025 Feb 12;28(Suppl. 1):i152.
    Link to: http://dx.doi.org/10.1093/ijnp/pyae059.263
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001419924100001
    顯示於類別:[陳慧諴] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI001419924100001.pdf1343KbAdobe PDF21檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋