國家衛生研究院 NHRI:Item 3990099045/16902
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    题名: Brain neuronal integrity in Covid-19 patients in Taiwan
    作者: Liu, TH;Wang, CH;Huang, SF;Tsou, HH;Yu, GY;Chen, ACH;Chen, WJ;Liu, YL
    贡献者: Center for Neuropsychiatric Research;Institute of Molecular and Genomic Medicine;Institute of Population Health Sciences;National Institute of Infectious Diseases and Vaccinology
    摘要: Background: COVID-19 has caused a global pandemic characterized by severe pneumonia. Brain structure abnormality has been confirmed in COVID-19 patients in the UK biobank [1]. However, it is not clear whether this abnormality is reversible nor if the abnormality could be detected in the early stage of the disease. Aims & Objectives: In this study, the pathological effect of COVID-19 on the brain integrity was monitored through the utilization of a brain injury bioindicator, neurofilament light chain (NFL) [2]. It can be released from the brain into the peripheral blood when the brain neuronal axon is injured [3]. The study aimed to assess the correlation between the discharge diagnoses and NFL levels in COVID-infected patients. Method: Plasma samples from the National Health Research Institutes (NHRI) Biobank of 400 COVID-19 patients recruited from 24 hospitals across Taiwan were used for NFL analyses by immunoassay. Results: Among the successfully analyzed 394 patients, 10 patients (2.5%) showed an NFL level above 200 pg/ml. The mean NFL levels were significantly higher in patients older than 50 years (P <0.0001). Male patients had a higher NFL level than females (P = 0.008). The increase in plasma levels of NFL was the highest in the first 1-7 days after the COVID-19 diagnosis was confirmed, then gradually decreased within a month. Significant higher NFL levels were observed in patients with hospitalization, respiratory or ICU treatment, and oxygen therapy (P <0.0001). Moreover, higher NFL levels were also correlated with discharge diagnoses of cardiovascular, lung, kidney, and other chronic diseases (P ≦ 0.008). Discussion & Conclusion: COVID-19 infection may cause brain neuronal injury especially in male patients older than 50 years. In addition, the plasma NFL level was associated with a number of clinical features. The results demonstrated that NFL could be an indicator for assessing the brain neuronal integrity following COVID- 19 infection.
    日期: 2025-02-12
    關聯: International Journal of Neuropsychopharmacology. 2025 Feb 12;28(Suppl. 1):i130.
    Link to: http://dx.doi.org/10.1093/ijnp/pyae059.225
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001420043200001
    显示于类别:[劉玉麗] 會議論文/會議摘要
    [陳為堅] 會議論文/會議摘要
    [黃秀芬] 會議論文/會議摘要
    [鄒小蕙] 會議論文/會議摘要
    [余冠儀] 會議論文/會議摘要

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