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http://ir.nhri.org.tw/handle/3990099045/16904
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| Title: | Differential risks of exposure to acrylamide in adult asthma clusters |
| Authors: | Hsu, YT;Wu, CC;Wang, CC;Sheu, CC;Yang, YH;Cheng, MY;Lai, RS;Cheng, MH;Chen, HC;Yang, CJ;Wang, CJ;Liu, HJ;Chen, HL;Hung, CH;Lee, CL;Huang, MS;Huang, SK |
| Contributors: | National Institute of Environmental Health Sciences;National Center for Geriatrics and Welfare Research;National Institute of Cancer Research |
| Abstract: | To the editor, The increase in asthma prevalence can be attributed more to environmental factors than genetic factors [1], and a significant degree of phenotypic heterogeneity in asthma is well recog-nized, but the underlying causes remain unclear. Exposure to acrylamide is primarily from occupational exposure, smoking, or dietary intake [2], posing a risk to the nervous and repro-ductive systems [3], but its potential adverse effect on asthma and the immune system remains to be defined. To evaluate the exposure to acrylamide and its varying effects on asthma and its phenotypes, we conducted a case–control study consisting of 365 participants with current asthma and 235 healthy controls (Tables S1 and S2). The study was approved by the ethics com-mittees of the National Health Research Institutes in Miaoli, Taiwan, the ethics committees of the participating hospitals, and informed consent from all participants.The case group had significantly higher levels of acrylamide metabolite in urine compared to controls (Table 1; median, 15.99 vs. 12.82 μg/g creatinine, p < 0.001). Logistic regression and multinomial logistic regression analyses revealed that higher urinary acrylamide metabolites levels were significantly associated with increased odds ratios for current asthma (ORs: 1.52, 95% CI: 1.04–2.24; Figure 1 and Table S3). Stratified by asthma phenotypes [4], significant acrylamide exposure risk was observed in Clusters E (young male current smokers with early- onset; OR: 1.84, 95% CI:1.16–2.92), A (older non- atopic females with late- onset; OR: 1.80, 95% CI: 1.28–2.51), C (older males with second- hand smoke exposure; OR: 1.70, 95% CI: 1.23–2.36), F (never smoking atopic males with early- onset; OR: 1.48, 95% CI: 1.02–2.13), and D (atopic females with high BMI and poor lung function; OR: 1.53, 95% CI: 1.05–2.21). To identify factors contributing to differences in acrylamide ex-posure, we performed a stratified analysis considering both occupational and non- occupational factors (Table S4). Among non- occupational factors, smoking, second- hand smoke ex-posure, and daily transportation by car and motorcycle were identified as potential contributors to the association with cur-rent asthma. Notably, we observed that commerce was associ-ated with the highest levels of acrylamide xposure. Analysis revealed that the primary contribution to this exposure came from Cluster A. Additionally, the level of an oxidative stress marker, HEL [5], was significantly correlated with urinary acrylamide metabolite in both cases and controls (Table 1; ρ = 0.48 and ρ = 0.25, respectively), as well as in Clusters A and B (ρ = 0.69 and ρ = 0.60, respectively).Clusters C and E, which had a history of smoking, highlight the increased risk of acrylamide exposure and the importance of identifying its sources [6]. For Cluster F, acrylamide exposure may have been associated with both workplace and household second- hand smoke exposure. Moreover, Cluster A mainly comprised non- atopic asthma females, whereas Cluster D was dominated by atopic females with a higher BMI. Cluster B mainly consisted of atopic females with a lower BMI, but urinary acrylamide metabolites were not considered crucial factors in environmental exposure. These three clusters highlighted potential variations in the sources of acrylamide exposure.In summary, this study provides novel evidence linking acryl-amide exposure to current asthma, using urinary metabolites as a reliable marker of exposure from various sources [7]. We observed significant differences in acrylamide exposure risk between asthma cases and controls, with varying levels across phenotypic clusters, highlighting the diverse environmental risk factors and their impact on asthma phenotypes. However, our study had some limitations, including the cross- sectional study design and the lack of dietary and detailed occupational exposure data, which limited our ability to establish causality and fully characterize acrylamide exposure sources. While identifying exposure sources is critical for public health, the primary aim of this study is to raise awareness of acrylamide exposure among asthma researchers and emphasize the need for future studies that integrate comprehensive exposure data and employ longitudinal designs to better understand the heterogeneity and its effects on asthma control. |
| Date: | 2025-02-15 |
| Relation: | Allergy. 2025 Feb 15;Article in Press. |
| Link to: | http://dx.doi.org/10.1111/all.16503 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001422294400001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85217713463 |
| Appears in Collections: | [黃嘯谷] 期刊論文
[其他] 期刊論文
[楊奕馨] 期刊論文
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| ISI001422294400001.pdf | | 191Kb | Adobe PDF | 17 | View/Open |
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