In this study, chemical screening of a zooxanthella-associated octocoral Junceella fragilis led to the identification of four briarane-type diterpenoids: one new compound, junceellolide Q (1), and three known analogs: fragilolide J (2), junceellin (3), and frajunolide N (4). The structures of compounds 2-4 were confirmed through single- crystal X-ray diffraction (SC-XRD) analysis, while the structure of compound 1 was elucidated using 2D-NMR techniques. Briaranes 1 and 2 were active in enhancing alkaline phosphatase (ALP) activity.
