國家衛生研究院 NHRI:Item 3990099045/1697
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1697


    Title: Risk factors of massive bleeding related to pancreatic leak after pancreaticoduodenectomy
    Authors: Tien, YW;Lee, PH;Yang, CY;Ho, MC;Chiu, YF
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: BACKGROUND: Most pancreatic leaks after pancreaticoduodenectomy were initially treated conservatively, and for the most part, they were self-limiting and closed spontaneously. But in a few patients, hemorrhage occurred 1 to 3 weeks postoperatively and remained a fatal complication after pancreaticoduodenectomy. STUDY DESIGN: To identify possible risk factors for massive bleeding, the medical records of 402 patients who had pancreaticoduodenectomies were reviewed for leak complications and analyzed for associations between the occurrence of massive bleeding and preoperative, intraoperative, postoperative, and pathologic parameters. RESULTS: In univariate logistic regression analysis, infectious clinical signs (p = 0.021, odds ratio [OR] = 7.06, 95% CI = 1.34, 37.12) and bile in the drainage fluid (p = 0.036, OR = 5.89, 95% CI = 1.13, 30.86) were associated with the risk of developing massive hemorrhage. This combination provided the highest estimate of massive bleeding after pancreatic leak (p = 0.005, OR = 8.57, 95% CI = 1.92, 38.35). CONCLUSIONS: Both infectious clinical signs and bile content in the drainage fluid considerably increase the risk of massive bleeding after pancreatic leak. Close observation of patients with these ominous signs is warranted.
    Keywords: Surgery
    Date: 2005-10
    Relation: Journal of the American College of Surgeons. 2005 Oct;201(4):554-559.
    Link to: http://dx.doi.org/10.1016/j.jamcollsurg.2005.05.007
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1072-7515&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000232433500010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=25844472660
    Appears in Collections:[Yen-Feng Chiu] Periodical Articles

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