國家衛生研究院 NHRI:Item 3990099045/16980

NHRI > National Institute of Cancer Research > Wun-Shaing Wayne Chang > Conference Papers/Meeting Abstract > Item 3990099045/16980

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16980

Title:	Long-term dynamic adaptation of multiple myeloma cells to the acidic extracellular microenvironment
Authors:	Chang, WSW;Chen, HL;Tsai, PC;Lin, SC
Contributors:	National Institute of Cancer Research
Abstract:	Multiple myeloma (MM) is the second most common blood cancer worldwide. Although significant improvements have been made with introduction of novel agents, relapsed or refractory MM is almost inevitable after a progression-free period. Unlike other hematological cancers, MM is often immersed in an acidic pH microenvironment. Few studies have attempted to address the acute impact of microenvironmental acidification on MM cells, but little is known about how tumor cells could sense, respond, reprogram, and ultimately adapt to the prolonged acidotic stress. Here, we generated and established a series of MM cell lines exposed to different time periods of extracellular acidity. We observed a distinct and long-term process of reversible adaptive eplasticity in acid-treated MM cells with altered proliferative responses, metabolic phenotype switches, reprogrammed mitochondrial dynamics and lipid droplet formation. Thirty-four target molecules were further identified to be significantly associated with the overall survival of MM patients - most of these were previously unable to be screened and detected by short-term analyses of the effects of microenvironmental acidity on MM cells
Date:	2025-01-03
Relation:	Cancer Science. 2025 Jan 03;116(S1):1029.
Link to:	http://dx.doi.org/10.1111/cas.16413
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001401044102278
Appears in Collections:	[Wun-Shaing Wayne Chang] Conference Papers/Meeting Abstract

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