國家衛生研究院 NHRI:Item 3990099045/16987
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    题名: Nitrogen, oxygen, and sulphur heterocycles as potent anti-inflammatory agents: Insight into the synthetic routes
    作者: Khadri, MJN;Shashikumar, U;Tsai, PC;Manjappa, KB;Ponnusamy, VK;Khanum, SA
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Nitrogen, oxygen, and sulfur-containing heterocyclic compounds are broadly established as key scaffolds with potential chemical and biological properties. Benzimidazole, indole, benzoxazole, benzothiazole, pyrazole, and thiophene analogs are significant heterocyclic motifs that bear almost all pharmacological activities. Anti-inflammatory activity is one of the most commonly associated biological activities with these heterocycles and thus has attracted the interest of researchers to synthesize and study them in-depth. The present review highlights mainly the various synthetic methodologies utilized to prepare these diverse heterocycles and their associated pharmacological properties limited to anti-inflammatory activities. Further, this review will provide a comprehensive idea of the methodologies used to prepare biologically active nitrogen, oxygen, and sulfur-bearing heterocycles and possibly invoke new thoughts in the search for rational designs for developing more promising anti-inflammatory agents.
    日期: 2025-03-05
    關聯: Chemistryselect. 2025 Mar 05;10(9):Article number e202403824.
    Link to: http://dx.doi.org/10.1002/slct.202403824
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2365-6549&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001437344600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=86000119169
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