國家衛生研究院 NHRI:Item 3990099045/1699
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1699


    Title: Multipoint linkage disequilibrium mapping using case-control designs
    Authors: Liang, KY;Chiu, YF
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Case-control study has been and continues to be one of the most popular designs in epidemiology. More recently, this design has been adopted to test for candidate genes when searching for disease genetic etiology. In this report, we present a multipoint linkage disequilibrium (LD) mapping approach with the focus on estimating the location of the target trait locus. It builds upon a representation, which shows that the difference between a case and a control in probabilities of carrying the target allele of a marker is proportional to that of the trait locus and that the proportionality factor is simply a measure of LD between the trait locus and the marker. Our method has the desired properties that (1) there is no need to specify phases of genotypic data with multiple markers, (2) it provides an estimate of location of the disease locus along with sampling uncertainty to help investigators to narrow chromosomal regions, and (3) a single test statistic is provided to test for LD in the framed region rather than testing the hypothesis one marker at a time. Our simulation work suggests that the proposed method performs well in terms of bias and coverage probability. Extension of the proposed method to account for confounding and genetic heterogeneity is discussed. We apply the proposed method to a published case-control data set for cystic fibrosis.
    Keywords: Genetics & Heredity;Public, Environmental & Occupational Health
    Date: 2005-12
    Relation: Genetic Epidemiology. 2005 Dec;29(4):365-376.
    Link to: http://dx.doi.org/10.1002/gepi.20104
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0741-0395&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000233657700006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=28344451992
    Appears in Collections:[Yen-Feng Chiu] Periodical Articles
    [Kung-Yee Liang] Periodical Articles

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