國家衛生研究院 NHRI:Item 3990099045/1701
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    題名: A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms
    作者: Chiu, YF;Liu, SY;Tsai, YY
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: We conducted genome-wide linkage scans using both microsatellite and single-nucleotide polymorphism ( SNP) markers. Regions showing the strongest evidence of linkage to alcoholism susceptibility genes were identified. Haplotype analyses using a sliding-window approach for SNPs in these regions were performed. In addition, we performed a genome-wide association scan using SNP data. SNPs in these regions with evidence of association ( P <= 0.0001) were identified. We found that the general patterns for nonparametric linkage (NPL) scores from SNP and microsatellite genome scans are fairly consistent; however, the peaks of the NPL scores are mostly higher in the SNP-based scan than those using microsatellite markers, which might be located at different regions. Furthermore, SNPs identified from linkage screens were not so strongly associated with alcoholism ( the most significant SNP had a p-value of 0.030) as those identified from association genomic screening ( the most significant SNP had a p-value of 2.0 x 10(-8)).
    關鍵詞: Genetics & Heredity
    日期: 2005-12-30
    關聯: BMC Genetics. 2005 Dec;6(Suppl. 1):Article number S89.
    Link to: http://dx.doi.org/10.1186/1471-2156-6-S1-S89
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236103400089
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=30344438421
    顯示於類別:[邱燕楓] 會議論文/會議摘要

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