國家衛生研究院 NHRI:Item 3990099045/1709
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12340/13512 (91%)
造访人次 : 2255168      在线人数 : 210
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1709


    题名: The negative correlation between plasma adiponectin and blood pressure depends on obesity: A family-based association study in SAPPHIRe
    作者: Li, HY;Chiu, YF;Hwu, CM;Sheu, WHH;Hung, YJ;Fujimoto, W;Quertermous, T;Curb, JD;Tai, TY;Chuang, LM
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: BACKGROUND The association between plasma adiponectin level and blood pressure remains inconclusive. Because obese subjects may have different mechanisms to regulate blood pressure, we hypothesized that obesity may be an important modifier. In order to minimize confounding effects from unidentified factors, a family-based design was employed to explore the relationship. METHODS A total of 1,048 subjects from 478 Chinese or Japanese families with a mean age of 50.4 +/- 9.0 years were included (the SAPPHIRe (Stanford-Asian Pacific Program in Hypertension and Insulin Resistance) cohort). Blood pressure was recorded automatically and the average of the last two out of three consecutive readings was used in the analysis. A subject with "hypertension" was defined as one with a systolic blood pressure (SBP) >= 140 mm Hg, or a diastolic blood pressure (DBP) >= 90 mm Hg, or who was already on medication for hypertension. Obesity was defined as having a body mass index (BMI) >= 25 kg/m(2) The updated homeostasis model assessment was used for calculating the indices of insulin sensitivity (HOMA2%S). Fasting plasma adiponectin was determined using radioimmunoassay. RESULTS Subjects with hypertension had significantly lower plasma adiponectin levels than those without hypertension (5.99 +/- 3.64 mu g/ml vs. 6.65 +/- 3.86 mu g/ml, P < 0.01). Plasma adiponectin level correlated negatively with hypertension after adjusting for age, sex, and HOMA2%S (odds ratio (OR) 0.94,95% confidence interval (CI) 0.90-0.98). In subjects without hypertension (n = 349), the plasma adiponectin level correlated negatively with SBP in those who were obese, after adjustment for age, sex, BMI, and HOMA2 %S (beta = -0.58, P = 0.03). The association was not significant in those without obesity. CONCLUSIONS Plasma adiponectin level correlates negatively with hypertension. In subjects without hypertension, the relationship between plasma adiponectin level and SBP depends on the presence of obesity.
    关键词: Peripheral Vascular Disease
    日期: 2008-04
    關聯: American Journal of Hypertension. 2008 Apr;21(4):471-476.
    Link to: http://dx.doi.org/10.1038/ajh.2008.5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0895-7061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000254137500025
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41349107631
    显示于类别:[邱燕楓] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    000254137500025.pdf162KbAdobe PDF688检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈