國家衛生研究院 NHRI:Item 3990099045/1730
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2594489      線上人數 : 336
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1730


    題名: The glycine allele of a glycine/arginine polymorphism in the Beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin
    其他題名: The glycine allele of a glycine/arginine beta(2)-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin
    作者: Ranade, K;Shue, WHH;Hung, YJ;Hsuing, CA;Chiang, FT;Pesich, R;Hebert, J;Olivier, M;Chen, YDI;Pratt, R;Olshen, R;Curb, D;Botstein, D;Risch, N;Cox, DR
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: Background: Several studies implicate polymorphisms in the human beta (2)-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area. Methods: We genotyped > 800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5' leader cistron another C/T transition that results in a glycine/arginine substitution at codon 16 (Gly16Arg), and a G/C transversion that causes, a glutamate/glutamine substitution at codon 27 (Glu27Gln). Results: The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70) for low-normal blood pressure the relative risk was 0.79 (95% CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population. There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population. Conclusions: The Gly16 allele in the beta (2)-adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin. (C) 2001 American Journal of Hypertension, Ltd.
    關鍵詞: Peripheral Vascular Disease
    日期: 2001-12
    關聯: American Journal of Hypertension. 2001 Dec;14(12):1196-1200.
    Link to: http://dx.doi.org/10.1016/S0895-7061(01)02213-0
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0895-7061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000172798200005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035217107
    顯示於類別:[熊昭] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    000172798200005.pdf70KbAdobe PDF670檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋