國家衛生研究院 NHRI:Item 3990099045/1731
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    题名: A polymorphism in the beta 1 adrenergic receptor is associated with resting heart rate
    其它题名: A polymorphism in the β1 adrenergic receptor is associated with resting heart rate
    作者: Ranade, K;Jorgenson, E;Sheu, WHH;Pei, D;Hsiung, CA;Chiang, FT;Chen, YDI;Pratt, R;Olshen, RA;Curb, D;Cox, DR;Botstein, D;Risch, N
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Resting heart rate is significantly associated with cardiovascular morbidity and mortality. However, the extent to which resting heart rate is genetically determined is poorly understood, and no genes have been found that contribute to variation in resting heart rate. Because signaling through the beta1 adrenergic receptor is a key determinant of cardiac function, we tested whether polymorphisms in this receptor are associated with resting heart rate. A cohort of 1 1,000 individuals of Chinese and Japanese descent, from nuclear families, was genotyped for two polymorphisms, resulting in a serine/glycine substitution at amino acid 49 (Ser49Gly) and an arginine/glycine substitution at residue 389 (Arg389Gly), in the beta1 adrenergic receptor. For comparison, polymorphisms in the beta2 and beta3 adrenergic receptors were also evaluated. The Ser49Gly polymorphism was significantly associated (P = .0004) with resting heart rate, independent of other variables, such as body-mass index, age, sex, ethnicity, exercise, smoking, alcohol intake, hypertension status, and treatment with beta blockers. The data support an additive model in which individuals heterozygous for the Ser49Gly polymorphism had mean heart rates intermediate to those of either type of homozygote, with Ser homozygotes having the highest mean heart rate and with Gly homozygotes having the lowest. Neither the Arg389Gly polymorphism in the beta1 adrenergic receptor nor polymorphisms in the beta2 and beta3 adrenergic receptors were associated with resting heart rate. The heritability of heart rate was 39.7% +/- 7.1% (P < 10(-7)).
    关键词: Genetics & Heredity
    日期: 2002-04
    關聯: American Journal of Human Genetics. 2002 Apr;70(4):935-942.
    Link to: http://dx.doi.org/10.1086/339621
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9297&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000174252100010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=18344377665
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