國家衛生研究院 NHRI:Item 3990099045/1732
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    题名: A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins
    作者: Ranade, K;Hinds, D;Hsiung, CA;Chuang, LM;Chang, MS;Chen, YT;Pesich, R;Hebert, L;Chen, YDI;Dzau, V;Olshen, R;Curb, D;Botstein, D;Cox, DR;Risch, N
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at similar to10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. (C) 2003 American Journal of Hypertension, Ltd.
    关键词: Peripheral Vascular Disease
    日期: 2003-02
    關聯: American Journal of Hypertension. 2003 Feb;16(2):158-162.
    Link to: http://dx.doi.org/10.1016/S0895-7061(02)03245-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0895-7061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000180636200012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=12244276719
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