國家衛生研究院 NHRI:Item 3990099045/1796
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1796


    Title: Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer
    Authors: Tseng, RC;Chang, JW;Hsien, FJ;Chang, YH;Hsiao, CF;Chen, JT;Chen, CY;Jou, YS;Wang, YC
    Contributors: Division of Biostatistics and Bioinformatics;Division of Molecular and Genomic Medicine
    Abstract: We extensively allelotyped a panel of 71 microdissected primary surgically resected non small cell lung cancer (NSCLC) tumors to identify chromosomal regions that are likely to contain tumor suppressor genes (TSGs) or associated with clinicopathologic and prognostic effects. Loss of heterozygosity (LOH) was detected by genotyping of 177 microsatellite markers and correlation of LOH with clinicopathologic parameters and prognosis was analyzed. Twenty markers showed an LOH frequency greater than 48%, and 8 of them (2p23.3, 2p24.3, 2q35, 6p22.2, 7p14.3, 7p22.2, 17q24.3 and 21q22.3) were novel in NSCLC. The high LOH regions were confirmed by further aligning continuous LOH regions from another set of 24 NSCLC tissues and defining 7 minimal deletion regions ranging from 1.29 to 12.26 cM. The aberrations of 8 markers showed a significant correlation with alteration of p16 and Rb proteins, suggesting the gene(s) located in the chromosomal loss that may interact with p16/Rb pathway. In addition, markers specifically associated with smoking, histology types and tumor stages were identified and the linked candidate TSGs were suggested. For example, marker D1S1612 closely linked with Mig-6 gene was associated with smoking patients, squamous cell carcinoma patients and late-stage patients. Furthermore, 3 markers, D2S2968, D6S2439 and D7S1818, were significantly associated with poor prognosis of NSCLC patients using both univariate and multivariate Cox's regression analyses (p = 0.035, 0.022 and., respectively). These markers can potentially be used for early In g cancer detection, outcome measurement and the positional cloning of new TSGs whose loss of function contributes to NSCLC tumorigenesis. (c) 2005 WileY-Liss, Inc.
    Keywords: Oncology
    Date: 2005-11-01
    Relation: International Journal of Cancer. 2005 Nov;117(2):241-247.
    Link to: http://dx.doi.org/10.1002/ijc.21178
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000232190900011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=25444439612
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles
    [Yuh-Shan Jou(1996-2005)] Periodical Articles

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