國家衛生研究院 NHRI:Item 3990099045/1806
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 855016      在线人数 : 933
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1806


    题名: Surrogate estimates of insulin sensitivity in subjects with hypertension
    作者: Hwu, CM;Hsiao, CF;Grove, J;Hung, YJ;Chuang, LM;T Chen, Y;D Curb, J;Chen, YDI;Rodriguez, B;Ho, LT
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: The purpose of the study is to compare surrogate estimates of insulin sensitivity with a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), in subjects with hypertension. Two hundred and twenty-eight hypertensive patients who received IST for SSPG were included for analysis. Estimates from fasting measurements alone, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), and indices from fasting and/or 2 h samples (ISI0,120 and ISITX) were calculated. In addition to Pearson and partial correlations, variance-component models were used to test the relationship between surrogate estimates of insulin sensitivity and SSPG. A large proportion of variance owing to covariates in the variance-component models indicated the goodness of model fit, irrespective of the independence among variables. SSPG was positively correlated with logarithmic transformation ( Log) (HOMA-IR) and negatively correlated with QUICKI, Log (ISI0,120) and ISITX ( all P<0.0001). Log ( ISI0,120) seemed to have a better correlation with SSPG (r = -0.72) than other measures in partial correlation. The proportion of variance owing to all covariates of Log (ISI0,120) and ISITX were larger than those of Log (HOMA-IR) and QUICKI in the variance-component models. After adjustments for demographic and obesity covariates, the proportion of variance explained by Log ( ISI0,120) were largest among the surrogate measures in the variance-component models. Our results showed that ISI0,120 and ISITX correlated better with SSPG than those used fasting measures alone (HOMA-IR and QUICKI). Log (ISI0,120) currently showing the strongest association with SSPG than other estimates is adaptable for use in large studies of hypertension.
    关键词: Peripheral Vascular Disease
    日期: 2007-03
    關聯: Journal of Human Hypertension. 2007 Mar;21(3):246-252.
    Link to: http://dx.doi.org/10.1038/sj.jhh.1002137
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9240&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000244275700007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33847062500
    显示于类别:[蕭金福] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    000244275700007.pdf112KbAdobe PDF585检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈