國家衛生研究院 NHRI:Item 3990099045/1810
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1810


    Title: Osteonecrosis in patients with human immunodeficiency virus type 1 infection in Taiwan
    Authors: Ho, YC;Shih, TTF;Lin, YH;Hsiao, CF;Chen, MY;Hsieh, SM;Sheng, WH;Sun, HY;Hung, CC;Chang, SC
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Osteonecrosis, a disabling complication associated with antiretroviral therapy (ART) and human immunodeficiency virus (HIV) infection, has rarely been reported in an Asian population. After an observation of 3,250 person-years (PY), 11 of 967 (1.1%) HIV-infected patients at a median age of 34 years developed osteonecrosis involving the hip joints (incidence, 3.4 per 1,000 PY). Their median CD4+ lymphocyte count had increased from 35 cells/mu L at the diagnosis of HIV infection to 297 cells/mu L at the diagnosis of osteonecrosis. The crude rate of osteonecrosis increased from 0% in patients without exposure to ART to 2.6 and 1.7% in patients with exposure to nucleoside reverse transcriptase inhibitors (NRTIs) and who had undergone highly active antiretroviral therapy (HAART) for 5 years or longer, respectively (P = 0.18 and 0.09, respectively). Among the patients receiving HAART, the estimated incidence of osteonecrosis was 4.2 per 1,000 PY. Patients with osteonecrosis had a longer duration of exposure to NRTIs (1,641 versus 1,264 days, P = 0.26) and to HAART (1,603 versus 1,251 days, P = 0.42), a higher serum triglyceride (median, 1, 130 versus 3 51 mg/dl; P = 0.09), and a higher proportion of lipodystrophy (81.8 versus 15.0%, P < 0.000 1). Our report suggests that osteonecrosis is a rare complication in HIV-infected patients with prolonged exposure to ART with resultant metabolic complications.
    Keywords: Infectious Diseases
    Date: 2007-11
    Relation: Japanese Journal of Infectious Diseases. 2007 Nov;60(6):382-386.
    Link to: http://www.nih.go.jp/JJID/60/382.html
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1344-6304&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000251401500012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36549038618
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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