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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1822


    Title: Improved outcomes of HIV-1-infected adults with tuberculosis in the era of highly active antiretroviral therapy
    Authors: Hung, CC;Chen, MY;Hsiao, CF;Hsieh, SM;Sheng, WH;Chang, SC
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Objectives: To compare the survival and treatment responses to antiretroviral therapy between HIV-1-infected patients with active TB (TB patients) and without (non-TB patients) in the era of highly active antiretroviral therapy (HAART). Design: 8-year prospective observational study at a university hospital. Methods: A total of 125 (17.5%) TB patients (median CD4 cell count at TB diagnosis, 37 X 10(6) cells/l) and 591 non-TB patients (CD4 cell count at enrolment, 79 X 10(6) cells/l) were prospectively observed between June 1994 and October 2002. Virologic and immunologic responses were assessed in 230 antiretroviral-naive non-TB patients and 46 TB patients who concurrently initiated antituberculous therapy and HAART. The clinical outcome was evaluated by comparing incidence of new AIDS-associated opportunistic illnesses (Ols) and survival of all TB and non-TB patients. Results: Among antiretroviral-naive patients, CD4 cell count increase (71 versus 64 X 10(6) cells/l, P = 0.70) and proportions of patients achieving undetectable plasma viral load 20 of 46 versus 107 of 230, relative risk (RR), 0.93; 95% confidence interval (95% CI), 0.65-1.34; P = 0.711 at week 4 of HAART were similar between the 46 TB and 230 non-TB patients, as was the virologic failure during HAART (RR, 1.49; 95% Cl, 0.92-2.41; P= 0.14). The risk for HIV progression to new Ols was also similar between the two groups (adjusted RR, 1.16; 95% Cl, 0.764-1.77). The adjusted hazard ratio for death of TB patients compared with non-TB patients was 1.18 (95% Cl, 0.65-2.32) before HAART era and 0.89 (95% Cl, 0.57-1.69) in HAART era. Conclusions: Our data indicated that virologic, immunologic, and clinical responses to HAART and prognosis of HIV-1-infected TB patients who were concurrently treated with antituberculous therapy and HAART were similar to those of non-TB patients. (C) 2003 Lippincott Williams Wilkins.
    Keywords: Immunology;Infectious Diseases;Virology
    Date: 2003-12-05
    Relation: AIDS. 2003 Dec;17(18):2615-2622.
    Link to: http://dx.doi.org/10.1097/00002030-200312050-00008
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0269-9370&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000220672800008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1642423917
    Appears in Collections:[蕭金福] 會議論文/會議摘要

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