國家衛生研究院 NHRI:Item 3990099045/1874
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    题名: Proton MR spectroscopy of the femoral head - Evaluation of patients at risk for avascular necrosis
    作者: Hou, CH;Shih, TTF;Liu, CY;Li, YD;Enright, T
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Purpose: To detect alteration of the fatty component by measuring the in vivo lipid and water content of normal-looking femoral heads of patients with and without risk for avascular necrosis (AVN) by using proton MR spectroscopy (MRS). Materials and Methods: Marrow composition was measured by proton MRS (TR/TE = 5000/20 msec) in a sample volume placed in the epiphysis of the intact femoral heads of patients with unilateral osteonecrosis of the hip (group 1, N = 61, then excluding the post-traumatic or steroid user, final N = 45) and age-matched controls (group 2, N = 49). Three response variables were derived from MRS: the lipid linewidth (LW), water LW, and lipid/water ratio. Results: Of the three variables, the lipid and water LWs differed significantly between groups (P < 0.001 and P = 0.05, respectively; t-test). The lipid/water ratio had border-line significance (P = 0.06). The three variables differed significantly between groups when multivariate regression (P < 0.0001) was analyzed; and age and sex had no significant effect on the three dependent variables. Conclusion: Proton MRS can depict alteration in the lipid and water composition of normal-looking femoral heads with and without AVN on the contralateral hip. Proton MRS may be a potential tool for investigating of the femoral head component in vivo and predicting the risk for development of AVN.
    关键词: Radiology, Nuclear Medicine & Medical Imaging
    日期: 2006-08
    關聯: Journal of Magnetic Resonance Imaging. 2006 Aug;24(2):409-417.
    Link to: http://dx.doi.org/10.1002/jmri.20653
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1053-1807&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000239410300021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746930563
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