國家衛生研究院 NHRI:Item 3990099045/1959
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    題名: Vancomycin-resistant Enterococcus (VRE) carriage and infection in intensive care units
    作者: Yeh, KM;Siu, LK;Chang, JC;Chang, FY
    貢獻者: Division of Clinical Research
    摘要: From July, 1997, through December, 2001, patients who were admitted to intensive care units (ICUs) were enrolled in the study of vancomycin resistance enterococcus (VRE) colonization. Among 4538 patients admitted to the ICUs, 363 (8.0%) patients were found to have positive culture of VRE at the day of admission to the ICUs and 453 (10.0%) of patients were negative to the first day of admission but became colonized with VRE during the stay in ICU. Among 816 patients, 9 (1.1%) with VRE isolated from sterile sites were selected for further analysis. Pulsed-field gel electrophoresis (PFGE) revealed a total of four PFGE banding patterns in the colonized and infected Enterococcus faecium isolates. Six of nine 9 were found to have an identical PFGE type la, suggesting the circulation of an endemic strain. All of these type la isolates also contained two potential virulence genes, the esp and hly genes and were first identified in Asia. After the further typing of 540 isolates that were randomly selected from each month, the endemic strain was not identified before the first patient was colonized and infected with this strain in November, 1998, but was isolated from other ICU patients during each month thereafter throughout the remainder of the study period. Although colonization of VRE is the first step toward infection, a low infection rate was observed, except in patients with prolonged hospitalization and severe illness. Use of the isolation room and reminders regarding hand hygiene failed to prevent the circulation of endemic strain. Thus, the SHEA guideline (Muto et al., Infect. Control Hosp. Epidemiol. 2003;24:362-386) for preventing nosocomial transmission of VRE should be enforced.
    關鍵詞: Infectious Diseases;Microbiology;Pharmacology & Pharmacy
    日期: 2004-06-01
    關聯: Microbial Drug Resistance. 2004 Jun 1;10(2):177-183.
    Link to: http://dx.doi.org/10.1089/1076629041310091
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1076-6294&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222491200014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3042730021
    顯示於類別:[蕭樑基] 期刊論文

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