國家衛生研究院 NHRI:Item 3990099045/2053
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    题名: Molecular epidemiology of long-term colonization of Candida albicans strains from HIV-infected patients
    作者: Li, SY;Yang, YL;Chen, KW;Cheng, HH;Chiou, CS;Wang, TH;Lauderdale, TL;Hung, CC;Lo, HJ
    贡献者: Division of Clinical Research
    摘要: Twenty-one Candida albicans isolates from three HIV-infected patients were collected over a period of 3 years and characterized for fluconazole susceptibility, infectivity and genetic relatedness. Fluconazole resistance was found in five isolates, four exhibited dose-dependent susceptibility and the remainder were fully susceptible to this agent. Pulsed-field gel clectrophoresis of SfiI restriction digests of the genomic DNA from the isolates revealed that isolates from the same swab specimen were identical despite differences in Susceptibility to fluconazole and isolates recovered over time from the three patients retained clonally related DNA fingerprints within each patient. This small-scale study confirms the persistence of oral colonization of C. albicans strains in HIV-infected patients. Clinical data also suggests that the primary infecting strain may become a persistent colonist in the oral cavity once the immune function of the patient has been restored.
    关键词: Public, Environmental & Occupational Health;Infectious Diseases
    日期: 2006-04
    關聯: Epidemiology and Infection. 2006 Apr;134(2):265-269.
    Link to: http://dx.doi.org/10.1017/S0950268805004905
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-2688&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236138600007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33244486781
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