國家衛生研究院 NHRI:Item 3990099045/2123
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    題名: HbiF regulates type 1 fimbriation independently of FimB and FimE
    作者: Xie, Y;Yao, YF;Kolisnychenko, V;Teng, CH;Kim, KS
    貢獻者: Division of Clinical Research
    摘要: Type 1 fimbriae have been suggested to play a role in the pathogenesis of extraintestinal Escherichia coli infection. Type I fimbriation in E. coli is phase variable and known to be dependent upon FimB and HIDE, the two recombinases that invert the molecular switch fimS and control the expression of the downstream fim operon. Here we showed that HbiF, a novel site-specific recombinase, inverted fimS independently of FimB and FimE. HbiF-mediated fimS inversion appeared to be predominantly switching from "off" (termed OFF) to "on" (termed ON) orientation. This is different from the fimS inversion mediated by either FimB (bidirectional ON to OFF and OFF to ON) or FimE (unidirectional ON to OFF). Constitutive expression of the hbiF gene in E. coli resulted in a fimS-locked-ON phenotype, which resulted in the pathogenic E. coli K1 strain being incapable of inducing a high degree of bacteremia in neonatal rats. Discovery of HbiF-mediated OFF-to-ON fimS switching provides a new opportunity to develop a strategy for the prevention and therapy of extraintestinal E. coli infection including bacteremia and meningitis.
    關鍵詞: Immunology;Infectious Diseases
    日期: 2006-07
    關聯: Infection and Immunity. 2006 Jul;74(7):4039-4047.
    Link to: http://dx.doi.org/10.1128/IAI.02058-05
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0019-9567&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000238591800036
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33745614095
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