國家衛生研究院 NHRI:Item 3990099045/2125
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    题名: Distribution patterns of dendritic cells and T cells in Diffuse large B-cell lymphomas correlate with prognoses
    作者: Chang, KC;Huang, GC;Jones, D;Lin, YH
    贡献者: Division of Clinical Research
    摘要: Purpose: Diff use large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphomas, accounts for 30% to 40% of all lymphoma cases. However, long-term survival by current chemotherapy was achieved in only 40% of patients, warranting the development of novel therapeutic strategies including T-cell immunotherapy. However, the level of baseline immune activation in DLBCL is unclear. Experimental Design: The density and distribution of dendritic cells and T cells in 48 cases of primary DLBCL was evaluated by immunohistochemistry. Results: Increased numbers of intraturnoral CD1a(+) dendritic cells and increased S100(+) cells and CD45RO(+) Tcells around the edges of the tumors were seen in 10 of 48 (21%), 9 of 48 (19%), and 10 of 48 (21%) cases and these were correlated with a favorable prognosis (P = 0.015; P = 0.070, and P = 0.017, respectively), along with increased granzyme B+ T cells in tumor beds (P = 0.013). Increased periturnoral T cells were correlated with tumor expression of HLA-DR (r = 0.446; P = 0.002). Extranodal lymphomas showed fewer tumor-associated CD45RO(+) Tcells (r = -0.407; P = 0.001) and less conspicuous dendritic cell infiltrates. Conclusions: In DLBCL, the presence of baseline antitumor immune response is associated with favorable clinical outcome, and thus adjuvant T-cell immunotherapy may further boost treatment responses.
    关键词: Oncology
    日期: 2007-11-15
    關聯: Clinical Cancer Research. 2007 Nov;13(22 Pt. 1):6666-6672.
    Link to: http://dx.doi.org/10.1158/1078-0432.CCR-07-0504
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1078-0432&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000251207100017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36749013021
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