國家衛生研究院 NHRI:Item 3990099045/2133
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2133


    Title: Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study
    Authors: Pan, TH;Chen, JW;Fann, C;Jou, YS;Wu, SY
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: A genetic linkage study of young-onset hypertension was performed on data from 59 nucleus families of Han Chinese residing in Taiwan. Thirty seven microsatellite markers near 18 hypertension candidate genes were genotyped. In a nonparametric identity-by-descent sibpair analysis, a positive linkage signal (defined as P<0.05) was found for four microsatellite markers, viz., D1S1612 (P=0.0162), D1S547 (P=0.0263), D8S 1145 (P=0.0284), and D17S2193 (P=0.0256), which were located ;near genes for atrial natriuretic peptide (NPPA)/glucose transporter 5 (SLC2A5), angiotensinogen (AGT), lipoprotein lipase (LPL), and angiotensin-conveting enzyme (DCP1), respectively. Marker D5S 1480 located near beta-2-adrenergic receptor (ADRB2) had a borderline P value (P=0.0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension.
    Keywords: Genetics & Heredity
    Date: 2000-09
    Relation: Human Genetics. 2000 Sep;107(3):210-215.
    Link to: http://dx.doi.org/10.1007/s004390000365
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-6717&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000089747100002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033771815
    Appears in Collections:[Yuh-Shan Jou(1996-2005)] Periodical Articles

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