國家衛生研究院 NHRI:Item 3990099045/2184
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2184


    Title: Analysis of T cell receptor V-beta gene usage during the course of disease in patients with chronic hepatitis B
    Authors: Dou, HY;Wu, JC;Peng, WL;Chang, CM;Chi, WK;Chu, YD;Hu, CP
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: The T cell receptor (TCR) is a heterodimeric molecule expressed on the surface of T cells and recognizes foreign peptides presented by the major histocompatibility complex on the surface of antigen-presenting cells or virus-infected cells. Analysis of TCR usage by T cells which recognize hepatitis B virus (HBV) provides further insight into the participation of T cell populations during the course of disease, In this study, we examined the T-cell-proliferative response and the TCR V beta gene usage of peripheral blood mononuclear cells in 3 patients with clinical evidence typical of chronic hepatitis B. All 3 patients had significant T-cell proliferative responses against HBV core antigen (HBcAg) during the remission stage, while no responses were detected during the acute exacerbation stage. In addition, the TCR V-beta 7 gene was utilized more frequently in T cells recognizing HBcAg during remission, while TCR V-beta 1 and V-beta 2 were utilized at a higher percentage during acute exacerbation. On the contrary, the T cell proliferative response against HBV surface antigen was undetectable and no specific V beta gene was utilized more frequently by all 3 patients, regardless of disease state. Our longitudinal studies, although based on a small sample of patients, demonstrate that the population of HBcAg-activated T cells alters during the course of disease in chronic hepatitis B patients.
    Keywords: Medicine, Research & Experimental
    Date: 1998-11
    Relation: Journal of Biomedical Science. 1998 Nov-Dec;5(6):428-434.
    Link to: http://dx.doi.org/10.1007/BF02255931
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000077465700004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031774238
    Appears in Collections:[Chung-Ming Chang] Periodical Articles

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