國家衛生研究院 NHRI:Item 3990099045/2215
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12340/13424 (92%)
造訪人次 : 2036749      線上人數 : 448
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/2215


    題名: Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
    作者: Jiang, SS;Chang, IS;Huang, LW;Chen, PC;Wen, CC;Liu, SC;Chien, LC;Lin, CY;Hsiung, CA;Juang, JL
    貢獻者: Division of Molecular and Genomic Medicine;Division of Biostatistics and Bioinformatics;National Institute of Cancer Research
    摘要: Baculoviruses, a family of large, rod-shaped viruses that mainly infect lepidopteran insects, have been widely used to transduce various cells for exogenous gene expression. Nonetheless, how a virus controls its transcription program in cells is poorly understood. With a custom-made baculovirus DNA microarray, we investigated the recombinant Autagrapha californica multiple nucleopolyhedrosis virus (AcMNPV) gene expression program in lepidopteran Sf21 cells over the time course of infection. Our analysis of transcription kinetics in the cells uncovered sequential viral gene expression patterns possibly regulated by different mechanisms during different phases of infection. To gain further insight into the regulatory network, we investigated the transcription program of a mutant virus deficient in an early transactivator (pe38) and uncovered several pe38-dependent and pe38-independent genes. This study of baculovirus dynamic transcription programs in different virus genetic backgrounds provides new molecular insights into how gene expression in viruses is regulated.
    關鍵詞: Virology
    日期: 2006-09
    關聯: Journal of Virology. 2006 Sep;80(18):8989-8999.
    Link to: http://dx.doi.org/10.1128/JVI.01158-06
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-538X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000240384800015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748490905
    顯示於類別:[莊志立] 期刊論文
    [林仲彥(1999-2005)] 期刊論文
    [熊昭] 期刊論文
    [張憶壽] 期刊論文
    [江士昇] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    000240384800015.pdf1244KbAdobe PDF1165檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋