國家衛生研究院 NHRI:Item 3990099045/2251
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    题名: IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells
    作者: Chang, KT;Tsai, CM;Chiou, YC;Chiu, CH;Jeng, KS;Huang, CYF
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Interleukin-6 (IL-6) has been identified as an important growth regulator of lung cancer cells. Elevation of serum levels of IL-6 has been found in a subpopulation of lung cancer patients, but rarely in patients with benign lung diseases. Approximately 15 % of non-small cell lung cancer (NSCLC) tumors exhibit neuroendocrine (NE) properties (NSCLC-NE) and have been suggested to have the biological characteristics similar to small cell lung cancer (SCLC) with early metastasis and initial responsiveness to chemotherapy. We recently showed that IL-6 promotes cell proliferation and downregulates the expression of neuron-specific enolase (NSE, one of the major NE markers) in NSCLC-NE cells. In this study, we show that IL-6 stimulates a transient increase of tyrosine phosphorylation of STAT3 in a dose-dependent fashion. Inhibition of STAT3 signaling pathway by either AG-490 (JAK2-specific inhibitor) or overexpression of STAT3Y705F (a dominant-negative STAT3) reverses NSE expression in IL-6treated NSCLC-NE cells. In addition, IL- 6 induces phosphorylation and activation of p38 MAPK. SB-203580, a p38 MAPK- specific inhibitor, inhibits IL-6-induced p38 MAPK phosphorylating activity and suppresses IL-6-stimulated cell proliferation. Together, our results indicate that STAT3 signaling pathway is involved in IL-6-induced NE differentiation and that p38 MAPK is associated with IL-6-stimulated growth regulation in NSCLC-NE cells. These data suggest that both kinase pathways play critical roles in the pathogenesis of NSCLC-NE malignancies, providing new molecular targets for future therapeutic approaches.
    关键词: Physiology;Respiratory System
    日期: 2005-09
    關聯: American Journal of Physiology-Lung Cellular and Molecular Physiology. 2005 Sep;289(3):L446-L453.
    Link to: http://dx.doi.org/10.1152/ajplung.00089.2005
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1040-0605&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000231395100011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=23944435400
    显示于类别:[黃奇英(1998-2005)] 期刊論文

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